Category: General
Posted by: agohaircom
Clin Genet. 2009Oct;76(4):332
Hereditary hair loss and the ancient signaling pathways....
Van Raamsdonk CD.
....hair, teeth, and nails, begin as a thickening of the ectoderm, called a placode. The placode arises from a primary induction signal that is sent from the underlying mesenchyme. The arrangement of hair follicles is due to the amount and distribution of signals that promote and inhibit hair placode formation. Continued development of a hair follicle after placode formation requires a complex cross-talk. Here, I will review recent studies in humans and mice that have increased our understanding of the role of these signaling pathways...in hereditary hair loss syndromes.....
Hereditary hair loss and the ancient signaling pathways....
Van Raamsdonk CD.
....hair, teeth, and nails, begin as a thickening of the ectoderm, called a placode. The placode arises from a primary induction signal that is sent from the underlying mesenchyme. The arrangement of hair follicles is due to the amount and distribution of signals that promote and inhibit hair placode formation. Continued development of a hair follicle after placode formation requires a complex cross-talk. Here, I will review recent studies in humans and mice that have increased our understanding of the role of these signaling pathways...in hereditary hair loss syndromes.....
27/11: Stroke,tempol, and Uric acid
Some of the same processes and agents that figure in hair loss and hair loss treatment also figure in stroke. All of this is at a very basic level of pathogenesis. E.g., see Dr proctor's paper on uric acid and stroke. Effective in both experimental animals of neuroprotection in stroke and in preventing uric-acid-induced kidney damage, TEMPOL (e.g.,) is effective in radiation-induced hair loss.
17/11: Hair loss blog
15/11: Hair regrowth and minoxidil
Minoxidil in hair loss treatment
Minoxidil stimulates hair regrowth. Sites of action include the papilla or matrix cells or possibly both. Biopsies from patients with male pattern hair loss show that the primary response is miniaturization. This is accompanied by shortening of the hair regrowth cycle. There is no evidence of follicular neogenesis. The site of action in hair loss treatment and hair regrowth is probably the papilla.
Minoxidil stimulates hair regrowth. Sites of action include the papilla or matrix cells or possibly both. Biopsies from patients with male pattern hair loss show that the primary response is miniaturization. This is accompanied by shortening of the hair regrowth cycle. There is no evidence of follicular neogenesis. The site of action in hair loss treatment and hair regrowth is probably the papilla.
07/11: Organic semiconductor
Category: General
Posted by: agohaircom
Not directly related to hair loss treatment. However, Dr Proctor has an early organic semiconductor device in the smithsonian Institution collection.
07/11: Dr Proctor treats hair loss
Dr Proctor treats hair loss
29/10: Hair Loss Treatment
There is also this Hair Loss blogspot
24/10: Hair loss in alpecia areata
Am J Dermatopathol. 1987;9:111
Hair loss due to alopecia areata involves the epidermis and the sebaceous glands
Piérard-Franchimont C, Piérard GE.
By using combined autoradiography and computerized image analysis, keratinocytes, sebaceous cells, and endothelial cells of the papillary dermis appear affected in hair loss secondary to alopecia areata. The atrophy and the reduction in the number of cells synthesizing DNA in these tissues resemble the changes observed in the hair follicles.
Hair loss due to alopecia areata involves the epidermis and the sebaceous glands
Piérard-Franchimont C, Piérard GE.
By using combined autoradiography and computerized image analysis, keratinocytes, sebaceous cells, and endothelial cells of the papillary dermis appear affected in hair loss secondary to alopecia areata. The atrophy and the reduction in the number of cells synthesizing DNA in these tissues resemble the changes observed in the hair follicles.
23/10: hair loss with a hamartoma
Am J Dermatopathol. 1987;9(5):428
Generalized hair follicle hamartoma: the third case report in association with myasthenia gravis.\
Weltfriend S, et al
A 29-year-old woman, referred because of the development of diffuse papules and plaques on the face and progressive hair loss, was found to have generalized hair follicle hamartoma, a very rare condition previously described in only two female patients. All three patients also suffered from myasthenia gravis. The histological appearance of both the involved and uninvolved skin was similar to trichoepithelioma.
Generalized hair follicle hamartoma: the third case report in association with myasthenia gravis.\
Weltfriend S, et al
A 29-year-old woman, referred because of the development of diffuse papules and plaques on the face and progressive hair loss, was found to have generalized hair follicle hamartoma, a very rare condition previously described in only two female patients. All three patients also suffered from myasthenia gravis. The histological appearance of both the involved and uninvolved skin was similar to trichoepithelioma.
Clin Genet. 1980;17:209
Autosomal recessive inheritance of atrichia congenita.
Cantú JM, et al
Two families, each with two sibs presenting with hair loss due to atrichia congenita, were studied. Histopathological studies of scalp biopsies from bald areas revealed absence of hair follicles. The pedigree data corroboratived the postulated autosomal recessive pattern of inheritance.
(edited)
Autosomal recessive inheritance of atrichia congenita.
Cantú JM, et al
Two families, each with two sibs presenting with hair loss due to atrichia congenita, were studied. Histopathological studies of scalp biopsies from bald areas revealed absence of hair follicles. The pedigree data corroboratived the postulated autosomal recessive pattern of inheritance.
(edited)
